He said reducing the steps to target dosing could help overcome clinical inertia. "In real-world practice, most patients never achieve the target doses of recommended heart failure medications ...

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Roche has stopped dosing in a phase 3 trial of tominersen, a potential Huntington’s disease (HD) drug developed with Ionis, after a pre-planned review by independent experts.

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We start it high and lower the dose if they can't tolerate it. If there's hyponatremia, I give them salt tablets. It's very similar to an SIADH [problem]. Whenever I see hyponatremia, I start them on ...