EurekAlert!5d
Landmark study of Chagas disease in Paraguay supports use of rapid tests to improve access to diagnosis
Rapid tests could be used to diagnose Chagas disease in resource-limited areas. The results of this research show that the prevalence of Chagas in an indigenous community in Paraguay is six times ...
SciELO15d
Investigation of the activity of 4-aminoquinolines as cysteine protease inhibitors with application in the treatment of Chagas disease
BACKGROUND Chagas disease (CD) is a neglected tropical disease caused by Trypanosoma cruzi. The current drugs used to treat ... To the Laboratório de Ressonância Magnética Nuclear (LAREMAR), UFMG, for ...
Frontiers16d
A short ncRNA modulates gene expression and affects stress response and parasite differentiation in Leishmania braziliensis
1 Laboratory de Molecular Parasitology, Department of Cell and Molecular ... We initially selected eight putative ncRNAs that were preferentially expressed in metacyclic or amastigote stages (Figure ...
eLife17d
Scrutinized lipid utilization disrupts Amphotericin-B responsiveness in clinical isolates of Leishmania donovani
This important study investigates the propensity of the intravacuolar pathogen, Leishmania, to scavenge lipids which it utilizes for its accelerated growth within macrophages. Although some of the ...
Frontiers22d
4-Aminoquinoline as a privileged scaffold for the design of leishmanicidal agents: structure–property relationships and key biological targets
Leishmaniasis is one of the most important neglected tropical diseases, with more than two million new cases annually. It is endemic in several regions worldwide, representing a public health problem ...