gut.bmj6d
Apoptosis of hepatic stellate cells: involvement in resolution of biliary fibrosis and regulation by soluble growth factors
associated with a fivefold decrease in activated HSC determined by α smooth muscle actin staining. TUNEL staining indicated that loss of activated HSC resulted from an increase in the rate of ...
eLife3d
Tissue-specific responses to TFAM and mtDNA copy number manipulation in prematurely ageing mice
This is an important and solid study that examines the role of TFAM, a protein that helps maintain mtDNA, in mtDNA mutator mice. The authors have demonstrated that TFAM's counteractive role in mtDNA ...
eLife3d
Enalapril mitigates aging by targeting antioxidative genes via phosphorylated Smad1/5/9
In summary, enalapril significantly mitigated multiple pathological markers associated with aging, including lipid droplets, amyloid, glycogen deposition, and fibrosis, in the brain, kidneys, liver, ...
The EMBO Journal2d
Portimine A toxin causes skin inflammation through ZAKα-dependent NLRP1 inflammasome activation
In 2020-2021, a mysterious skin disease affected fishermen in Senegal. High levels of Portimine A toxin, produced by the ...
The EMBO Journal5d
Proteogenomic analysis reveals adaptive strategies for alleviating the consequences of aneuploidy in cancer
Aneuploidy is frequent in cancer, but in vitro it triggers multiple cellular stresses and often delays proliferation. Through ...