and Furuichi et al., revealed that certain viral and eukaryotic mRNAs have a cap — a methylated guanosine residue linked to the 5′ end of mRNA through an inverted 5′ to 5′ triphosphate bridge.

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Alternatively, researchers can also modify the chemical structure of the mRNA cap found at the molecule’s 5’ end. The naturally-occurring cap structure typical in mammalian cells has a ...

When developing mRNA therapeutics, capping technology plays a crucial role in determining the stability, translation efficiency and immunogenicity of synthetic mRNAs. Advancements in ...