Immunoassay or Mass Spec? In secondary care, Lumipulse p-tau217 and MS p-tau217 or %p-tau217 are similarly accurate. In primary care, the latter performs best when only one cutoff is used (top).

Single and multi-dose studies of the small molecule TREM2 agonist VG-3927 clear early safety hurdle. Meanwhile, new findings ...

Evidence suggests that in Parkinson’s disease, a breakdown in lysosomal function allows lipids to build up within cells. Variants of the GBA1 gene, the strongest genetic risk factor for sporadic PD, ...

Alzforum webpages for each DIAN-TU-eligible variant now state “DIAN-TU eligibility: Yes” near the top of the page and an explanation under the Pathogenicity section (see, for example, PSEN1 M146V ).

Space, An Early Frontier. When a brain region is tau-negative by SUVR (green arrow, left), spatial extent (dark blue) correlates better with measures of disease severity than does SUVR (light blue).

For one, microglia hovering around plaques—the type that express the most TREM2—reportedly become desensitized to stimulation ...

It binds both transmembrane and soluble TREM2, triggering a rise in CSF sTREM2. Single and multi-dose studies of the small ...

Unger was able to nip calcium transients in the bud by injecting a “puff” of sTREM2 into the mouse brain with a pipette; this temporarily silenced nearby neurons, and it did so in wild-type or TREM2 ...

Do you know a conference you think we should list? Let us know by sending us an email with the details to conferences@alzforum.org.

Vaccine Step Down. A person’s probability of developing dementia over seven years increased with age. It was higher in the ...

A new consortium aims to speed the pace of basic science discovery in AD and related diseases. A future AI assistant is to ...