O-GlcNAcylation in humans is mediated by a single essential enzyme, O-GlcNAc transferase (OGT ... these data indicate a role for SFSWAP as a global negative regulator of pre-mRNA splicing and positive ...

Synthetic biology products serve life sciences researchers across a variety of healthcare applications, including drug discovery, disease detection, enzyme engineering, gene editing and basic ...

Researchers from the International Institute of Molecular and Cell Biology in Warsaw (IIMCB) have described a new mechanism ...

Heidelberg biochemists and structural biologists from Shanghai unravel the roles of two key regulatory factors in mRNA ...

The introns need to be cut out of the pre-mRNA in the cell nucleus and the exons reconnected at the interfaces. This process is known as splicing. Ultimately, the spliced messenger RNA consists of ...

RNA splicing is a modification of the nascent pre-messenger RNA (pre-mRNA) transcript in which introns are removed and exons are joined prior to translation. For many eukaryotic introns ...

Researchers have discovered that mRNA-based COVID-19 vaccines have a persistent effect on the innate immune system. These mechanisms may help the human body to better protect itself against ...

They found that mRNA-based COVID-19-vaccinations cause a significant and persistent change through acetylation, i.e., the binding of a chemical group to specific, immunologically relevant genes of ...

The evolution of low-temperature adapted enzymes Scientists uncover how enzymes evolved to function at low temperatures by reconstructing prehistoric proteins from extinct bacteria Date: March 25 ...

The vaccine — using messenger RNA (mRNA) technology similar to that found in some Covid vaccines — activated tumour-targeting immune cells that persisted for nearly four years after surgery in ...