Professor Hirohide Saito (Department of Life Science Frontiers at CiRA / The University of Tokyo) and Assistant Professor ...

This unique property facilitates membrane fusion-mediated endosomal escape, leading to improved mRNA expression in the liver compared to conventional phospholipids such as DSPC and DOPE. "Endosomal ...

The R&D Day showcased Everest's proprietary mRNA platform driven by AI and its three leading pipeline assets in cancer and autoimmune disease: the personalized cancer vaccine (PCV) EVM16, the ...

Investigating how mutations in tumors alter DNA’s 3D structure—and subsequently, regulatory sequences called enhancers—can ...

Summary: New research reveals how a tiny chemical mark on RNA helps wire the brain during development. Scientists discovered ...

Additionally, mRNA expression lasted up to four weeks -- significantly longer than the typical five-day expression period of LNPs. Notably, ...

In addition, ME Therapeutics is exploring design modifications of its mRNA candidates to modulate mRNA expression in a tissue-specific manner for increased efficacy and safety. About ME Therapeutics.

For the first time, systemically delivered programmable mRNA was used to safely target expression of IL-12 into cancerous tissue while inhibiting expression in healthy tissue,” said Jacob ...

In recent years, mRNA technology enabled the rapid development of vaccines to fight COVID-19, saving millions of lives. That same mRNA-powered approach to medicine—in which synthetic mRNA is ...