m6A is a chemical modification found on mRNA molecules. It regulates various cellular processes, including mRNA stability and degradation, and plays a role in controlling protein synthesis. The role ...

They found that the ribosome does more than just read the mRNA – it searches for m6A on the molecule and ensures that mRNAs with the modification are targeted for degradation. The scientists ...

They found that the ribosome does more than just read the mRNA – it searches for m6A on the molecule and ensures that mRNAs with the modification are targeted for degradation. The scientists ...

Figure 3. Drosophila m6A pathway. (A) m6A writers and readers. (B) Mapping of m6A modifications (miCLIP track) relative to mRNA-seq identifies extensive modification in the intronic regions (CIMS, ...

More information: Xin-Hui Chen et al, Regulations of m6A and other RNA modifications and their roles in cancer, Frontiers of Medicine (2024). DOI: 10.1007/s11684-024-1064-8 ...

And, crucially, adding modifications to the bases in the synthetic mRNA—specifically, pseudouridine (Ψ), 5-methylcytidine (m5C), N6-methyladenosine (m6A), 5-methyluridine (m5U) or 2-thiouridine ...

α-Synuclein binds P-body proteins, disrupting these mRNA-processing organelles. Synuclein stabilizes transcripts, slowing their degradation. Genetic variants that impair P-body proteins associate with ...

The life of an mRNA ultimately results in its removal by degradation, i.e., breaking it down. For pathways involving the exosome, the aim of the study was to determine whether the individual ...