The Cleveland Guardians don't boast big names outside Steven Kwan and Jose Ramirez but make the postseason regularly. They are coming off a 2024 season, where they made it to the ALCS.

Preview the May 21 matchup between the Minnesota Twins and Cleveland Guardians with odds over/under, game spread, betting lines and more.

Get Minnesota vs Cleveland baseball betting preview, spread and over/under insights for their matchup on May 21.

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