Since B12 is a water-soluble vitamin, it’s generally considered safe, even at high doses. No Tolerable Upper Intake Level (UL) has been established for B12, due to its low level of toxicity.

after which he added the drug in a toxic dose, which would lead to the death of people’. Yegor Semenov was convicted in a closed-door military trial (Picture: Newsflash/NX) There were 77 guests ...

A drug’s therapeutic index is a ratio that doctors use when prescribing medications and determining dosage. It shows how much of a drug a person’s blood can contain before it becomes toxic.

The dose limiting toxicity (DLT) dose level has not been identified in doses up to 250 mg/day. Systemic exposure increased with increased doses of NXP900, achieving clinically relevant ...

Reduced-dose radiotherapy in head & neck cancer shows similar efficacy to standard dose but with lower toxicity, per findings from the UPGRADE-RT trial. Reduced-dose definitive radiotherapy (RT) ...

In modern society, it’s entirely safe to browse through books, but for centuries, flipping through the pages of a single tome could have devastating health consequences, as toxic chemicals were ...

In order to receive a toxic dose of fluoride, an adult weighing 155 pounds would need to drink almost 120 gallons of water at once. “The major source of fluoride toxicity remains oral hygiene ...

CytoAgents Inc. completed the dose-limiting toxicity observation for the first cohort in a trial targeting CRS in blood cancer patients. The Safety Review Committee approved dose escalation for the ...

Heterogeneous escalation of radiotherapy dose guided by imaging in locally advanced non–small cell lung cancer (NSCLC) does not increase early toxicity, a new trial found. “Patients with ...

The PTC readthrough level induced by GK-Ae at the middle dose (1 mM) was comparable to that induced by G418 at a maximum non-toxic dose (0.3 mM). To determine whether GK-Ae can stabilise mRNAs, ...

“The necessity to do more with less is prompting studies exploring lower doses.” Besse argued that de-escalation strategies could save patients from unnecessary toxicity, reduce time spent in ...