Fusion genes, arising from abnormal chromosomal rearrangements, are gaining recognition as pivotal players in cancer ...

Scientists at St. Jude Children's Research Hospital and Dana-Farber Cancer Institute today report the identification of a novel combination therapy approach to treat pediatric acute myeloid leukemia ...

SNARE proteins are a large family of membrane fusion proteins. As a lot of human diseases are related to the SNARE proteins, they have attracted people to study them. Traditionally, the SNARE proteins ...

Membrane fusion is a critical process enabling cargo transfer between membrane-bound compartments. The soluble NSF attachment protein receptor (SNARE) proteins are key mediators of membrane fusion and ...

We collect all SNARE proteins from the UniProt database according to the keyword SNARE. To avoid the homology of the SNARE protein sequence data that we collect, we use BLAST to address the redundancy ...

N-terminal SNARE GST fusion proteins (SNAP-25, SNAP-25E, syntaxin-1A, and VAMP2) are expressed in Escherichia coli BL21 (DE3) competent cells. Cells are grown at 37°C in LB medium with ampicillin (100 ...

Its lead asset, DSP107, is a bi-functional fusion protein that targets CD47 and 4-1BB. It triggers a local, synergistic immune response by binding both CD47, over-expressed on cancer cells, thereby ...

SNARE proteins, known as membrane fusion proteins, play a primary role to mediate vesicle fusion. Loss of function of the SNARE protein can lead to a variety of diseases. A method to accurately ...

Vesicle fusion is mediated by assembly of SNARE proteins between opposing membranes. While previous work suggested an active role of SNARE transmembrane domains (TMDs) in promoting membrane merger ...

In 2013, the Nobel Prize in Physiology or Medicine was awarded to three scientists for their contributions to uncovering the mechanisms governing vesicle transport in cells. Their explanations ...

At the heart of this Nobel Prize-winning intracellular process lies SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptors), a superfamily of 60 proteins in mammalian cells that ...