A riboswitch can adopt different secondary structures to effect gene regulation depending on whether ligand is bound. This schematic is an example of a riboswitch that controls transcription. When ...

Although the diversity of natural riboswitches (or that of their target molecules) is limited, a riboswitch responsive to a user-defined molecule can be artificially created. In fact, some natural ...

The riboswitch was designed to regulate the expression of human erythropoietin (hEPO). This protein is used to treat anemia associated with chronic kidney disease and is an attractive target for ...

The SAM-I, SAM-II, and SAM-III riboswitch classes are members of the SAM riboswitch family. The aptamer domain from each class has unique secondary (top row) and tertiary (bottom row) structural ...

To prevent a global health crisis, scientists around the world are searching for ways to fight bacteria that can evade the current arsenal of antibiotics.

Our proprietary splicing-based riboswitch platform is superior to other inducible gene expression systems with unprecedented dynamic range, demonstrated ability to regulate any transgene, and ...

RNA self-regulation is as complex and sophisticated as protein-based gene regulation, according to a report in Science this week. A novel Bacillus subtilis riboswitch as described by the authors is an ...

In experiments at SLAC's Linac Coherent Light Source, riboswitch crystals and adenine molecules were pumped into a mixing chamber, where they were allowed to interact for carefully timed intervals ...

In a discovery that points to potential new antibiotic medicines, scientists have deciphered the workings of a common but little-understood bacterial switch that cuts off protein production.

This particular riboswitch resides in the messenger RNA that carries instructions for the enzyme responsible for the production of glucosamine-6-phosphate, called GlmS.

The riboswitch is specific enough that it doesn't bind caffeine, which is structurally similar to theophylline. The bacteria migrate as a function of theophylline concentration, heading toward ...

A research team at Merck (accidentally) uncovered a new antibacterial target - a riboswitch important for riboflavin (vitamin B2) biosynthesis. The team screened nearly 60,000 small molecules for ...