Pseudoisocytosine (J), a neutral analogue of protonated cytosine, is currently the gold standard modified nucleobase in peptide nucleic acids (PNAs) for the formation of J·G-C triplets that are stable ...

In our system, the multivalency of the system is further increased by the three tandem ZnF domains in PARP1 (Fig. 3) and by the PAR chains, which are nucleic acid-like polymers of up to 200 ADP-ribose ...

In medicine and biotechnology, the ability to evolve proteins with new or improved functions is crucial, but current methods are often slow and laborious. Now, Scripps Research scientists have ...

The nucleic acid-based biosensor technologies are useful to precisely detect genetic footprints at low concentrations with high specificity and selectivity. They commonly rely on incorporating nucleic ...

Noncanonical nucleic acid conformations like G-quadruplexes and i-motifs are key regulators of gene function, genome stability, and drug action. Their structural dynamics in extreme conditions of high ...