As discussed below, anti-integrin therapies may represent such a novel anti-invasive therapy.

She added, “There remains a considerable unmet medical need for the 30% to 40% of DME patients who do not respond to current ...

Previous studies have shown that α9-integrin expression and activation in mature dorsal root ganglion neurons enable the regeneration of injured axons within the spinal cord. However, tissue ...

Here, we examine whether Notch signalling mediates vascular endothelial growth factor (VEGF) and angiopoietin 2 (Ang2)-induced vascular function. Results Notch-1 IC and Notch-4 IC protein expressions ...

HRG treatment promoted NRF2 nuclear translocation in a time-dependent manner. Furthermore, activation of NRF2 significantly reduced TNF-α-induced tube formation and integrin expression, suggesting ...

A substantial and persuasive body of data now exists that supports the view that integrin alpha V beta 3 plays a critical part in activated macrophage dependent inflammation, osteoclast development, ...

Sabanci University Nanotechnology Research and Application Center, Istanbul 34956, Turkey Sabanci University Faculty of Engineering and Natural Sciences, Istanbul 34956, Turkey Sabanci University ...