Polysome-qPCR can quantify the polysome distribution and translation rate of IRES-containing mRNA isoforms in an isoform-sensitive manner from embryonic tissues. A key reason for our poor ...

Antonia was not always a scientist, beginning her higher education with a joint science and arts degree at the University of Guelph in 2015. After exploring her interests in a range of non ...

KCL Department of Biophysics: glass and acetate slides ('quarter plates', 'whole plates' and 'half plates') relating to the work of the Medical Research Council (MRC) Biophysics Research Unit (KCL ...

Add a description, image, and links to the polysome-profiling topic page so that developers can more easily learn about it.

Specifically, portimine A was found to target the 60S ribosomal export protein NMD3, blocking polysome formation and inhibiting protein translation and was observed to be an effective agent for ...

Writing in Science Advances researchers of the University of Cologne describe a key mechanism that controls the decision-making process that allows human embryonic stem cells to make the heart.

Decision letter after peer review: Thank you for submitting your article "Polysome-CAGE of TCL1-driven chronic lymphocytic leukemia revealed multiple N-terminally altered epigenetic regulators and a ...

Polysomal profiling has emerged as a tool to identify mRNAs that are actively translated. The association of the mRNA to the polysome, also referred to as translatome, provides a proxy for mRNA ...

Polysome profiling, the first translatomics technique, has been valuable in translational studies – uncovering dynamics of ribosome occupancy and density. Ribosome profiling is another promising ...

We found that K63 ubiquitinated ribosomes are also present in a polysome arrangement, similar to that observed in yeast polysomes, which we determined using cryoelectron tomography (cryo-ET). We ...