The global burden of chronic kidney disease (CKD) is rising, with more than 800 million people affected worldwide. Vascular ...

The strength of evidence was convincing through the use of complementary and sophisticated tools, accompanied by rare isolation of human diseased lung blood vessel cells that were source-matched to ...

1University of Colorado Cancer Center, University of Colorado Anschutz Medical Campus, Aurora, Colorado. 3Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado.

New York, Apr 4: Scientists have made a significant breakthrough in cancer treatment with the development of an ultrasound-activated CAR T-cell therapy, which shows potential for long-lasting tumour ...

Testicular germ cell tumors (TGCT) are the predominant tumor in younger males. Usually, 5-year survival rates are quite high, but 15-20% of patients with metastatic non-seminomas are resistant to ...

Department of Endocrinology, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of University of Science and Technology of China (USTC), Division of Life ...

Our data show that PAC-1 modulates sunitinib-induced autophagy and blocks lysosomal trapping, potentiating sunitinib activity and increasing death of cancer cells. As both drugs are well-tolerated in ...

29Developmental Biology and Cancer Department, UCL GOS Institute of Child Health, London, United Kingdom. 32Haematology and Oncology Department, Great Ormond Street Hospital, London, United Kingdom.

Correct mitotic spindle alignment is essential for tissue architecture and plays an important role in cell fate specification through asymmetric cell division. Spindle tethering factors such as ...

A new study on the genetic causes of the PTEN Hamartoma Tumour Syndrome ... affecting endothelial cells, the ones lining the inner layer of blood vessels, lead to vascular malformations.

We differentiated induced pluripotent stem cells from risk, nonrisk donors at 9p21.3, and isogenic knockouts into vascular smooth muscle cells (VSMCs). We performed single-cell transcriptomic ...