RT-PCR and sequencing revealed a small amount of normal-size mRNA with normal exon 1-exon 2 splicing. Quantitative RT-PCR on mutant LMSF showed AR mRNA levels were well below 10% of normal ...

Ultimately, we selected eight candidate variants to assess their effects on pre-mRNA splicing. The numbering of DNA variants ... respectively (Figure 2A), which correspond to the normal transcripts ...

However, when cancer disrupts this process, it can drive tumor growth and survival by altering normal splicing patterns ... A graphic illustration of a poison exon being removed from pre-mRNA. The ...

Heidelberg biochemists and structural biologists from Shanghai unravel the roles of two key regulatory factors in mRNA ...

Researchers have discovered that mRNA-based COVID-19 vaccines have a persistent effect on the innate immune system. These mechanisms may help the human body to better protect itself against ...

Most people have been taught a body temperature of 98.6 Fahrenheit is normal, while 100.4 or above indicates a fever. But a TikTok user recently went viral when she said her normal body ...

They found that mRNA-based COVID-19-vaccinations cause a significant and persistent change through acetylation, i.e., the binding of a chemical group to specific, immunologically relevant genes of ...

uses a powerful monitoring system to reveal how the human immune system is responsive to a litany of tick triggers — some of which might be leveraged to create a protective mRNA vaccine.

The vaccine — using messenger RNA (mRNA) technology similar to that found in some Covid vaccines — activated tumour-targeting immune cells that persisted for nearly four years after surgery in ...

Key suits were filed by third party mRNA and lipid pioneers that, while not having any mRNA-based products on the market themselves, leveraged their patent portfolios claiming a share of the ...