correlated well with the prediction from MAP POD affinities that HSD would be a difficult target. Indeed, follow-up lead optimization efforts from HTS against HSD did not find any drug-like leads ...

Understanding drug–target interactions is essential to improve leads, optimize pharmacokinetics and predict in vivo efficacy. The process of generating soluble, functional drug targets and studying ...

strategic decision making with respect to drug discovery project management, from the initial steps in therapeutic target identification to ligand generation and the ensuing lead-optimization ...

Results from a new study published in Clinical and Translational Immunology found that dual-target antibody therapy can enhance cancer-fighting T cells more effectively than current single-target ...