Axon guidance cues direct nerves in the heart during development, disease and regeneration. These cues determine cardiac innervation patterning by regulating the balance between chemo-attraction and ...

TM6SF2 GKO mice fed an HFD showed elevated liver and intestinal lipid deposition compared to CON mice. The gut microbiota of HFD-fed TM6SF2 GKO mice exhibited a decreased Firmicutes/Bacteroidetes ...

The Ca2+ stored in the cellular endoplasmic reticulum (ER) plays a crucial role in protein folding and lipid transfer, and its impairment leads to cellular ER stress. When chronic cellular ER stress ...

JONATHAN LAMBERT, BYLINE: Neuroscientist Li Zhang has anesthetized a lot of mice for his research. Several years ago, as he brought these knocked-out mice back to their cages, he started noticing ...

Li and his colleagues took a different approach. The team used gene editing to knock out imprinted genes altogether. Around 200 of a mouse’s genes are imprinted, but Li’s team focused on 20 ...

Collaborating with study co-authors Zachi Horn, a former postdoc in the Hatten lab, and with assistance from Shiaoching Gong, of Weill Cornell Medicine, Hanzel spent two years creating a knockout ...

2009). Heterozygous KO mice were intercrossed to generate homozygous KO mice (Parisiadou et al., 2009). This knock-out (KO) model was generated by deleting exon 2 of the Lrrk2 gene, which results in a ...

Cats have not been seen as an everyday mice infestation solution for some time now. But when we see a little rodent scurry across our kitchen floors, we can't help but wish we had a feline friend to ...

Researchers at Baylor College of Medicine have received a grant for more than $12 million from the National Institutes of Health for a third five-year phase of the Knockout Mouse Phenotyping Program ...

(Getty Images) The University of California, Davis, has been awarded just over $12 million from the National Institutes of Health under the third and final five-year phase of the Knockout Mouse ...