Researchers have found new compounds that could be used to treat a common breast cancer that can be resistant to hormone ...

More information: Andrew Brennan et al, An Intracellular Peptide Library Screening Platform Identifies Irreversible Covalent Transcription Factor Inhibitors, Advanced Science (2025). DOI ...

Their previous work identified reversible inhibitors of cJun, but this latest work builds on that by discovering peptides that bind selectively and irreversibly within cells, permanently blocking ...

A young mother who was 36 weeks pregnant when she suffered “irreversible brain damage” died as a result of a ruptured brain aneurysm, an inquest has heard. Saoirse McElvaney, a 26-year-old ...

State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, International ...

Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland ...

Janus kinase inhibitors (JAKis) are an important treatment option for people with chronic inflammatory diseases such as rheumatoid arthritis, psoriasis, Crohn's disease or ulcerative colitis.

The research team found that not only was RAS(ON) multi-selective inhibition effective in preclinical pancreatic cancer models, but it was even more effective when combined with immunotherapy ...