This useful study shows a protective role of type 1 IFN during Mycobacterium tuberculosis infection. It shows that the type 1 IFN response in human skin TST inversely correlates with TB severity, ...

Fontolizumab (HuZAF) is the humanised form of a murine antihuman IFN-γ antibody (Protein Design Labs ... Screening for circulating antibodies to fontolizumab was performed using a bridging ELISA.

Macrophages from wild-type or Stat1 KO mice were incubated in the presence or absence of IFN-γ for 60 hours, at which time, supernatants were assayed for interleukin-6 (IL-6) levels by ELISA ...

The supernatant was measured for IFN-γ using the ClinMax ™ Human IFN-γ ELISA kit. These measurements revealed that NK cells co-cultured with K562 secreted greater levels of IFN-γ than the ...

Indeed, the current study is built upon the foundational work of Zhang et al. (PMID: 23175475), which first described the proinflammatory IFN-γ + phenotype of CD4 T cells in CD11c-p28 floxed mice ...

Objective: Interferon-γ release assay (IGRAs) promised a sensitive and specific diagnosis of latent and active infection of Mycobacterium tuberculosis(M.tb). Therefore, the intent of this study was to ...