Post-translational modifications (PTMs) of histones are an essential feature in the dynamic regulation of chromatin. One of these modifications, ubiquitylation, has been speculated to directly ...

Previously, we reported the semisynthesis of ubiquitylated histone H2B (uH2B) using two orthogonal expressed protein ligation reactions. Semisynthetic uH2B, when incorporated into nucleosomes, ...

Gene Hackman, Wes Anderson, Bill Murray on the set of 2001's 'The Royal Tenenbaums' Buena Vista Pictures/Courtesy Everett Collection Ahead of the Cannes premiere of his latest film, The Phoenician ...

Doctors announced this week that they have treated a newborn baby with a rare genetic disease using the world’s first personalized gene editing therapy. Geoff Bennett discussed the treatment and ...

Gene therapy. Gene therapy is an innovative treatment that aims to cure disease at the source, by editing the DNA causing the problem. The scientists working on KJ's case used CRISPR, ...

News broke yesterday that researchers in Philadelphia appear to have successfully treated a 6-month-old baby boy, called KJ, with a personalized CRISPR gene-editing therapy.The treatment corrects ...

The goal is to reuse key parts of the treatment and simply swap in a custom set of instructions for each patient's specific gene mutation, doctors say.

KJ Muldoon became the first patient to undergo personalized CRISPR treatment, a therapy that found the one uniquely mutated gene out of 20,000 in his little body, and fixed it.

The rapid-fire attempt to rewrite the child’s DNA marks the first time gene editing has been tailored to treat a single individual. The baby who was treated, Kyle “KJ” Muldoon Jr., ...

A Japanese research team led by Kyushu University professor Hiroyuki Sasaki has said it discovered a gene that determines the color patterns of the tricolored calico cat, known in Japan as mike neko.

KJ can now follow a diet richer in proteins – his condition prohibited such before – and does not need as much medicine as he used to. KJ's parents, Kyle and Nicole, and his three siblings are looking ...