Prostaglandin E2 (PGE2), a bioactive lipid derived from arachidonic acid, mediates a broad range of physiological processes ...

Taste, pain, or response to stress—nearly all essential functions in the human body are regulated by molecular switches ...

A nanobody was identified that targets the N-terminal fragment of the adhesion G-protein-coupled receptor ADGRG2, allosterically enhances activation by the natural agonist dehydroepiandrosterone ...

The reported cryo-EM imaging of a pentameric ligand-gated ion channel in liposomes as opposed to nanodiscs has both broad implications and contributes valuable methodological advances to the ...

Scientists discovered a hidden CB₁ receptor pocket and engineered a drug to exploit it, offering promise of safer, more ...

Septerna's GPCR platform shows promise, but execution risks, funding needs, and competition suggest caution. Click here to ...

Prostaglandin E2 (PGE2), a bioactive lipid derived from arachidonic acid, mediates a broad range of physiological processes through four G ...

Method reveals unexpected behavior in molecular crowding during cell state transitions and suggests density as a biomarker for functional precision medicine.

MIT researchers found a way to measure cell density quickly and accurately — measuring up to 30,000 cells in a single hour. They also showed density changes could be used to make useful predictions, ...

Scientists have created a new type of super-strong antibody that could significantly enhance cancer immunotherapy. In an ...