The long β-hairpin, absent in the mammalian homologs of α-lytic protease that lack large folding barriers, may contribute to this coupling of fluctuations, perhaps by capping the C-terminal β ...

protein folding and amyloid formation are separated by the supersaturation barrier of a denatured protein. Breakdown of this supersaturation barrier is required to shift the protein to the amyloid ...

These proteins often fold intotheir three-dimensional structures by crossing only a single barrier.The barrier consists of an ensemble of extremely short-lived transitionstate structures which ...