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The UPR is activated by the accumulation of unfolded proteins in the ER due to various factors (top left of figure). BiP binds to unfolded proteins, leading to dissociation of IRE1a and IRE1b.

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Make data more insightful with free, online, collaborative spreadsheets. Microsoft Copilot in Excel unlocks the latest AI capabilities to help you achieve your goals—from creating a simple spreadsheet ...