Wade Wilson has taken on some of the most powerful beings in the Marvel Universe, even going face-to-face with cosmic forces ...

Deadpool was put into the Ravencroft Institute, the Marvel version of Arkham Asylum, but instead of having an actual doctor trying to help him, Deadpool had the mind-controlling Psycho-Man.

Now, in Deadpool Kills the Marvel Universe One Last Time #4, he'll face one of his toughest challenges ever as he battles the Doctor Doom of an alt-reality. But he's not totally unprepared.