Unlike typical DIAD progression, tau pathology in this case was confined to the occipital lobe without spreading, suggesting a possible explanation for the lack of cognitive decline. DIAD results ...

DIAD results from highly penetrant mutations in amyloid precursor protein (APP), presenilin 1 (PSEN1), or PSEN2, which lead to abnormal amyloid-β processing and early-onset Alzheimer's disease.