A new review reveals how lactate and its derivative lactylation process drive breast cancer progression, opening new ...

Aging and neurodegeneration are both known to disrupt the production of functional proteins in cells—a process called "proteostasis," or protein homeostasis. Brain cells in particular fall prey ...

This study identifies a mechanism by which secondary differentiation is initiated in Chlamydia and reveals a critical role for the second messenger signaling molecule c-di-AMP in this process.

A new study shows how an anticancer drug triggers an “outside in” signal that gets it sucked into a cancer cell. The work, published Jan. 29 in Nature Communications, reveals a new signaling mechanism ...

THE biologic role of cyclic AMP (adenosine 3′,5′-monophosphate), at least as it is understood today, is shown in Figure 1. After release from an endocrine gland, a hormone is transported to ...

The findings identify a novel non-synaptic signaling mechanism between the brain and peripheral sensory system important for migraine.

Cyclic adenosine 3′,5′-monophosphate (cAMP) is one of the most studied signaling molecules that plays a critical role in cellular responses to extracellular stimuli in the cardiovascular system.

Phosphodiesterases (PDE) degrade cAMP and thereby regulate the duration and intensity of cAMP signaling. EPAC function in a PKA-independent manner and represents a novel mechanism for governing ...

BACKGROUND: 3′, 5′-cyclic AMP (cAMP) regulates numerous cardiac functions. Various hormones and neurotransmitters elevate intracellular cAMP (i[cAMP]) in cardiomyocytes through activating GsPCRs ...

The cyclic GMP-AMP synthase-stimulator of interferon genes signal transduction pathway is critical in innate immunity, infection, and inflammation. In response to pathogenic microbial infections and ...

Bacteria possess an array of defenses against foreign invaders, including a broadly distributed bacteriophage defense system termed CBASS (cyclic oligonucleotide-based anti-phage signaling system). In ...

Cellular signaling pathways involved in everything from the proliferation of fatty tissue to the death of neurons in the brain are tightly regulated by "cascades" of sequentially activated enzymes ...