Breast cancer is becoming increasingly treatable, but in some cases the disease can resurface even decades after a patient ...

Since 2014, she leads her own research team in Weill Cornell Medicine in New York studying the critical interplay between TFs, 3D chromatin organization and transcription during cell cycle or cell ...

Cell cycle-related kinase (CCRK ... Design Transcriptional regulation was assessed by chromatin immunoprecipitation, promoter mutation and luciferase reporter assays. Hepatocellular proliferation and ...

A generalizable Hi-C foundation model for chromatin architecture, single-cell and multi-omics analysis across species. bioRxiv, 2024. Paper @article{wang2024hicfoundation, title={A generalizable Hi-C ...

Areas of emphasis include cell cycle and senescence; cell death and survival; chromatin, gene and RNA regulation; DNA damage and repair; genomics; oncogenes and tumor suppressors; and signal ...

demonstrated that targeting cell cycle and cell fate regulatory programs blocks non-genetic cancer evolution in acute lymphoblastic leukemia. Findings from Olle Sangfelt's group at the Department of ...

In order to harness the full potential of the immune system T and NK cells need to colonize tumors as well as to display optimal tumor killing potential. We investigate the ability of T and NK cells ...

The epigenetic reader MeCP2 binds to methylated cytosines on the DNA and regulates chromatin organization ... incubation systems are listed in Supplementary Table S5. For the cell cycle analysis, the ...

Studying how lungs develop has helped us understand and treat often-devastating lung diseases. This includes diseases like cystic fibrosis which result from spelling mistakes known as mutations in a ...

Chromatin Structure: the proteins of this group regulate gene expression during neurogenesis and assure proper DNA damage repair. Cytokinesis: the proteins of this group regulate the terminal step in ...