In light of this, our laboratories have undertaken studies of cardiac chromatin organization in the context of cardiovascular disease. 1, 2 The approach to this question involved using HiC technology ...

Embedded Multi-die Interconnect Bridge-T (EMIB-T) was a prominent highlight of the Intel Foundry Direct Connect event. Intel is promoting this advanced packaging technology as a key building block for ...

This will help develop a better understanding of the ways in which chromatin packaging shape gene expression and, ultimately, lifespan in C. elegans. The research is funded by a grant from the ...

More information: Yinu Wang et al, Chromatin Organization Governs Transcriptional Response and Plasticity of Cancer Stem Cells, Advanced Science (2025). DOI: 10.1002/advs.202407426 ...

Synopsis Cryo-electron tomography allows the investigation of nucleosome-level chromatin structure and to test different chromatin compaction models. This study improves sample preparation, revealing ...

Synopsis Cryo-electron tomography allows the investigation of nucleosome-level chromatin structure and to test different chromatin compaction models. This study improves sample preparation, revealing ...

Chromatin is one of the most complex materials in cells and enables the massive amount of DNA in the genome to fold up and fit into the nucleus of each cell. The building blocks of this genetic ...

The scientists observed that chromatin self-organizes into "packing domains"—distinct, compact regions of molecular structures that play a crucial role in regulating gene expression.

The re-expression of fetal cardiac genes during disease requires coordinated chromatin remodeling. Local chromatin packing around the nucleosome protein complex is understood with atomic resolution; ...

We present herein a minimal model based purely on molecular, physical, and statistical principles which (1) preserves the efficiency of chromatin packing, (2) produces the structural heterogeneity and ...

In comparing the effects of the folding parameter, α, with the overall chromatin volume fraction, ϕ, we show that just two parameters can recapture the heterogeneous nature of chromatin observed in ...

Abstract. The dynamic organization of chromatin, governed by epigenetic modifiers, critically regulates cell plasticity and determines cell fate in both normal and malignant stem cells. We ...