This thesis investigates how human cells carry out the critical task of packaging copied DNA. We developed human cells in which this process can be quickly turned off, allowing us to study the ...

Chromatin remodelling can result from covalent modification of histones by histone acetyltransferases, histone deacetylases, histone methyltransferases or kinases, and by ATP-dependent protein ...

Chromatin structure is thought to regulate transcription factor access by modulating DNA accessibility. Here, the authors show that in living human cells, euchromatin and heterochromatin are fully ...

The tumor suppressor p53 is a transcription factor that controls the expression of hundreds of genes. Emerging evidence suggests that the p53-induced RNA-binding protein ZMAT3 is a key splicing ...