Here we use cryogenic electron microscopy to determine the structure of TbAQP2 from Trypanosoma brucei, bound to either the substrate glycerol or to the sleeping sickness drugs, pentamidine or ...

Studies presented at the ASCO Annual Meeting 2025 highlighted immunotherapies that may provide new standards of care for certain cancers as well as immunotherapies that are breaking new ground by ...

We have developed a streamlined proteomic sample preparation protocol termed Accelerated Barocycler Lysis and Extraction (ABLE) that substantially reduces the time and cost of tissue sample processing ...

This article makes a valuable contribution to the field by uncovering a molecular mechanism for miRNA intracellular retention, mediated by the interaction of PCBP2, SYNCRIP, and specific miRNA motifs.

Activated T cells form an immunological synapse with tumor cells, resulting in tumor cell lysis and the release of cytokines (e.g., IFN-γ, TNF-α, IL-2, IL-10), which boost T cell proliferation and ...

CHICAGO -- The bispecific T-cell engager tarlatamab (Imdelltra) significantly prolonged survival in the second-line treatment of small cell lung cancer (SCLC), a practice-changing phase III trial ...

protocol 3. biobrick™ 3a assembly and gel analysis; protocol 4. agarose gel electrophoresis; protocol 5. preparation of competent e. coli cells using cacl 2; protocol 6. transformation of cacl ...