As early as 1975, the triad of GI mucosal injury, presence of bacteria in the gut, and introduction of a metabolic substrate (eg, feedings) was proposed as the etiology of bowel necrosis (Fig 2).

Adequate bowel length was preserved in infants with massive intestinal necrosis, allowing for their survival. There was no major morbidity in study infants, and only 30% required a second surgery.

Pediatric infliximab biosimilar use has risen significantly, reflecting evolving treatment patterns in inflammatory bowel ...

Hemorrhagic necrosis of the bowel may also be caused by bacterial endotoxin through a Shwartzman phenomenon, as reported in infants 12 and laboratory animals. 13 The intestine in such cases, ...

Tumor necrosis factor is a protein involved in inflammation. Excess tumor necrosis factor (TNF) in the blood has a role in inflammatory conditions, such as forms of arthritis and irritable bowel ...

Association Between Tumor Necrosis Factor-α Antagonists and Risk of Cancer in Patients With Inflammatory Bowel Disease. JAMA , 2014; 311 (23): 2406 DOI: 10.1001/jama.2014.5613 Cite This Page : ...

Necrotizing enterocolitis (NEC) is a life threatening gastrointestinal disorder that can cause bowel inflammation in newborns. To help diagnose and classify NEC, doctors may use a variety of ...

With progression to frank necrosis of bowel, peristalsis ceases, and the signs of generalized peritonitis become apparent. Fever and vascular collapse are present.