Adequate bowel length was preserved in infants with massive intestinal necrosis, allowing for their survival. There was no major morbidity in study infants, and only 30% required a second surgery.

As early as 1975, the triad of GI mucosal injury, presence of bacteria in the gut, and introduction of a metabolic substrate (eg, feedings) was proposed as the etiology of bowel necrosis (Fig 2).

Tumor necrosis factor is a protein involved in inflammation. Excess tumor necrosis factor (TNF) in the blood has a role in inflammatory conditions, such as forms of arthritis and irritable bowel ...

Roughly 15% of ischemic colitis cases progress to bowel necrosis when part of the tissue in the intestines dies due to a lack of blood supply. Without prompt diagnosis and treatment, ...

Hemorrhagic necrosis of the bowel may also be caused by bacterial endotoxin through a Shwartzman phenomenon, as reported in infants 12 and laboratory animals. 13 The intestine in such cases, ...

A 4-year-old male presented with sudden, constant, and intense abdominal pain that woke him from sleep. He previously had been healthy, without any changes in bowel habits, nausea, or vomiting ...

Association Between Tumor Necrosis Factor-α Antagonists and Risk of Cancer in Patients With Inflammatory Bowel Disease. JAMA , 2014; 311 (23): 2406 DOI: 10.1001/jama.2014.5613 Cite This Page : ...

In a recent study published in Scientific Reports, researchers compared changes in inflammatory bowel disease (IBD) treatment strategies before and after the introduction of biologics in Japan ...

With progression to frank necrosis of bowel, peristalsis ceases, and the signs of generalized peritonitis become apparent. Fever and vascular collapse are present.

Pediatric infliximab biosimilar use has risen significantly, reflecting evolving treatment patterns in inflammatory bowel ...