The MEILB2 protein sandwich carries the BRCA2 protein precisely to the DNA break points. To determine the structure of this BRCA2 complex, the researchers used X-ray crystallography.

However, this ‘yin and yang’ concept does not appear to correlate well with the positive role that BRCA2 protein plays in RAD51-mediated recombination. To understand the molecular function of ...

To determine the functions of BRCA2, the human protein was purified. It was found to bind selectively to single-stranded DNA (ssDNA), and to ssDNA in tailed duplexes and replication fork structures.

Scientists have taken pictures of the BRCA2 protein for the first time, showing how it works to repair damaged DNA. Mutations in the gene that encodes BRCA2 are well known for raising the risk of ...

Three separate groups have isolated the BRCA2 protein that is involved in inherited cases of breast and ovarian cancer. The researchers hope that better understanding of the protein and how it ...

People with mutations in a DNA repair protein called BRCA2 are predisposed to breast, ovarian and prostate cancers, which often develop at a young age. In the clinic, these cancers are treated ...

Women with a BRCA1 or BRCA2 mutation have up to a 72% chance of breast cancer during their lifetime. Normally, the PALB2 gene makes a protein that works with the BRCA2 gene protein to repair ...

Two mice were chosen for splenectomy and cell fusion on the basis of the specificity for C-terminal BRCA2 protein by using the immune response initial testing strategy. Clonal supernatants were ...

“We just wanted to look for differences that changed the function of the protein between primates and humans.” The BRCA2 protein plays a crucial role as a tumor suppressor. It is responsible for ...

'[M]ethylglyoxal triggers the destruction of BRCA2 protein, reducing its levels in cells.' 'This effect is temporary, but can last long enough to inhibit the tumor-preventing function of BRCA2.

One novel observation was that especially in BRCA1-mutation recurrent cancers, the tumor cells often have switched to expressing a specific isoform of the BRCA2 protein's messenger-RNA molecule.

ANN ARBOR—The initials BRCA2 may be best known for a gene associated with many cases of breast cancer, and the protein encoded by the BRCA2 gene is critical to repairing breaks in DNA.