The MEILB2 protein sandwich carries the BRCA2 protein precisely to the DNA break points. To determine the structure of this BRCA2 complex, the researchers used X-ray crystallography.

To determine the functions of BRCA2, the human protein was purified. It was found to bind selectively to single-stranded DNA (ssDNA), and to ssDNA in tailed duplexes and replication fork structures.

Scientists have taken pictures of the BRCA2 protein for the first time, showing how it works to repair damaged DNA. Mutations in the gene that encodes BRCA2 are well known for raising the risk of ...

People with mutations in a DNA repair protein called BRCA2 are predisposed to breast, ovarian and prostate cancers, which often develop at a young age. In the clinic, these cancers are treated ...

Women with a BRCA1 or BRCA2 mutation have up to a 72% chance of breast cancer during their lifetime. Normally, the PALB2 gene makes a protein that works with the BRCA2 gene protein to repair ...

'[M]ethylglyoxal triggers the destruction of BRCA2 protein, reducing its levels in cells.' 'This effect is temporary, but can last long enough to inhibit the tumor-preventing function of BRCA2.

Two mice were chosen for splenectomy and cell fusion on the basis of the specificity for C-terminal BRCA2 protein by using the immune response initial testing strategy. Clonal supernatants were ...

“We just wanted to look for differences that changed the function of the protein between primates and humans.” The BRCA2 protein plays a crucial role as a tumor suppressor. It is responsible for ...

Cancer cells can somehow tolerate the loss of the BRCA2 pathway, but when the PARP1 protein is inhibited, they die." Ryan Jensen, associate professor of therapeutic radiology and pathology at Yale ...

One novel observation was that especially in BRCA1-mutation recurrent cancers, the tumor cells often have switched to expressing a specific isoform of the BRCA2 protein's messenger-RNA molecule.

ANN ARBOR—The initials BRCA2 may be best known for a gene associated with many cases of breast cancer, and the protein encoded by the BRCA2 gene is critical to repairing breaks in DNA.

Scientists have taken pictures of the BRCA2 protein for the first time, showing how it works to repair damaged DNA. Mutations in the gene that encodes BRCA2 are well known for raising the risk of ...