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BP1 is a key player in DNA repair and together with BRCA1 regulate selection of DNA double strand break repair mechanisms. Localization of DNA repair factors to sites of DNA damage by 53BP1 is ...

While poly (ADP-ribose) polymerase (PARP) inhibitors have primarily transformed clinical outcomes through the synthetic lethality mechanism, their long-term ... and redox homeostasis disruption (BRCA1 ...

Germline mutations in the BRCA1 gene increase the lifetime risk of breast cancer to as high as 80%. Preventive measures and early detection strategies remain limited, largely due to an incomplete ...

5-year survival for stage III and IV (%): carriers, 38.1; noncarriers, 24.5 Median survival: p = 0.002 5-year survival for stage III and IV: p < 0.001 [46] Time of first relapse (years): BRCA ...

It is recommended that prophylactic surgery should be performed as soon as possible, simply because of the early development of cancer in BRCA mutation carriers. Although ovarian cancer rarely ...

It is a possible maintenance treatment for advanced high-grade epithelial ovarian, fallopian tube or primary peritoneal cancer after a complete or partial response to first-line platinum-based ...

This summary report is based on the NICE assumptions used in the resource impact template. Users can amend the 'Inputs and eligible population' and 'Unit costs' worksheets in the template to reflect ...

Gene sequencing studies have uncovered mutations in key oncogenes responsible for colorectal cancer (CRC) development. CRC tumors exhibit significant heterogeneity, and a subset of tumors harbor other ...

Physicians can offer people with certain inherited mutations -- such as those in two BRCA genes, which are known to increase breast cancer risk -- options to reduce their risk of developing cancer.