The regenerating cellular elements, believed to be alveolar lining cells ... more probably, chronic hypoxia brings about decreased pulmonary perfusion, so that the vascular phase of ...

Hypoxic patients may not be dyspneic and, if they are, correcting the hypoxia does not necessarily ... reducing the work of breathing and improving alveolar ventilation. 81 It has long been ...

Besides, alveolar macrophages and interstitial macrophages display ... Peli1 leads to decreased macrophage activation and reduced pulmonary artery remodeling in hypoxia-induced PH mice. 8 These ...

It is concluded that the obligatory hypoventilation necessary to restore depleted body CO 2 stores may result in hypoxia in the first hour after operation. The importance of this subtle and short ...

Hypoxia-driven gene and protein changes enhance epithelial-to-mesenchymal transition, remodel the extracellular matrix, drive drug resistance, support cancer stem cells and aid evasion from immune ...

At low lung volumes, alveolar collapse leads to hypoxic pulmonary vasoconstriction of extra-alveolar vessels. Thus, it is imperative to use adequate end-expiratory pressure to optimize the ...

Umut A. Gurkan is leading the CASE Biomanufacturing and Microfabrication Laboratory (CASE-BML). Dr. Gurkan’s research is focused on microcirculation, vascular biology, red blood cells, hemoglobin, ...

Since MSCs are typically administered into naturally hypoxic tissues, understanding the impact of hypoxia on the functioning of MSCs is crucial. Hypoxia has been postulated to be among the factors ...

Some of the injuries in CCHS are progressive, likely an aftermath of hypoxia and these secondary consequences, and interventions may be available to prevent at least a portion of the damage. Figure 3.