For the first time, researchers have filmed in real time the disassembly of DNA at the atomic scale. This strand separation is the first step in DNA replication. This breakthrough, published ...

However, despite decades of study, many aspects of helicase function remain unclear, including the exact mechanics of strand separation, how ATP hydrolysis drives movement, and how helicases ...

Using cutting edge cryo-electron microscopy, the team of scientists were able to visualise a helicase enzyme (nature's DNA unzipping machine) in the process of unwinding DNA. DNA helicases are ...

Using cutting edge cryo-electron microscopy, the team of scientists were able to visualise a helicase enzyme (nature's DNA unzipping machine) in the process of unwinding DNA. DNA helicases are ...

Then, a protein known as helicase attaches to and breaks apart the hydrogen bonds between the bases on the DNA strands, thereby pulling apart the two strands. As the helicase moves along the DNA ...

Using cryo-electron microscopy and deep learning to observe the helicase Simian Virus 40 Large Tumor Antigen interacting with DNA, the laboratories of KAUST Assistant Professor Alfredo De Biasio ...

By binding uniquely to the helicase domain of WRN, IDE275 (GSK959) delivers potent and selective inhibition across MSI-H models," said Michael White, Ph.D., Chief Scientific Officer, IDEAYA ...

How does the cell protect these strands from damage? How would you identify the protein that serves as a connector between DNA helicase and pol-a/primase? A simple yet often effective approach is ...

MOMA-313, a potentially best-in-class, highly potent and selective Polθ helicase inhibitor with a favorable emerging safety profile, recently advanced into the combination arm of a Phase 1a dose ...

Using cutting edge cryo-electron microscopy, the team of scientists were able to visualise a helicase enzyme (nature’s DNA unzipping machine) in the process of unwinding DNA. DNA helicases are ...

4 IDEAYA/GSK presentations of IDE275 (GSK959) and 4 additional presentations across IDE397/MAT2A, IDE161/PARG, PRMT5, and KAT6/7 programs at AACR 2025 IDE275 (GSK959) has demonstrated a potential ...