What's the difference between mRNA and pre-mRNA? It's all about splicing of introns. See how one RNA sequence can exist in nearly 40,000 different forms.

How does the splicing machinery distinguish between exons, which are part of the mature mRNA, and introns, which are removed from the pre-mRNA? Alternative splicing adds an extra layer of ...

Esophageal squamous cell carcinoma (ESCC) is a highly aggressive malignancy with poor prognosis, and understanding the ...

These circular RNAs are generated when the pre-mRNA splicing machinery “backsplices” and joins a splice donor to an upstream splice acceptor (Figure 1). Once produced, it is largely unclear what ...

Scientists at the University of California, Irvine, have discovered that nuclear speckles, a membraneless organelle within the nucleus, serve as central hubs for pre-mRNA 3′ end processing. This ...

We study minor spliceosome which is a parallel pre-mRNA splicing machinery in the cells of most metazoan organisms. Our main aim is to investigate mechanism and regulation of this nuclear machinery, ...

Further investigation into alternative splicing events showed how nematode infection modulates pre-mRNA splicing, affecting gene function and protein diversity. Validation using a transgenic hairy ...