However, they suggested that future mRNA vaccines be designed with molecules that prevent protein-making machinery from "slipping" around the mRNA strand. This would help cells read the mRNA more ...

My biggest concern regarding Moderna is that it's limited. Human immune systems go berserk when they notice a free-floating mRNA strand. This is why all of Moderna's commercial-stage drugs and ...

Heidelberg biochemists and structural biologists from Shanghai unravel the roles of two key regulatory factors in mRNA ...

By virtue of complementary base- pairing, this action creates a new strand of mRNA that is organized in the 5' to 3' direction. As the RNA polymerase continues down the strand of DNA, more ...

but all of these ribosomes must begin at the first codon and move along the mRNA strand one codon at a time until reaching the stop codon. This group of ribosomes, also known as a polysome ...

Discover how an emerging technology called tRNA therapy could become the next big thing in genetic disease treatment.

Scientists at Shinshu University School of Medicine have developed a synthetic mRNA that, when injected, revitalizes the immune system to recognize and attack metastasizing cancer cells.

Expert Rev Vaccines. 2012;11(1):55-67. A summary of the events taking place after intradermal injection of naked mRNA is given inFigure 1. Although formulation of mRNA vaccines and sophisticated ...

Cells express their genes by converting the genetic message into protein. This process of protein synthesis occurs in two stages - transcription and translation. When a gene is to be expressed ...