mRNA splicing is a fundamental part of the ... a process facilitated by splicing enzymes. In the new study, the Caltech ...

From splicing and polyadenylation ... Over the past five years, most of the enzymes involved in mRNA decay have been identified and we are beginning to unravel the complex regulation that ...

How can only 25,000-30,000 protein-coding genes in humans produce the massive variety of proteins, cells, and tissues that exist in our bodies? The answer: alternative splicing. A critical finding ...

Research into splicing mechanisms and patterns is essential for decerning fundamental biological principles, as well as clarifying the molecular basis of many diseases and developing new therapies. 2 ...

Heidelberg biochemists and structural biologists from Shanghai unravel the roles of two key regulatory factors in mRNA ...

RNA repair enzymes capable of sealing 2’,3’-cyclic-PO 4 /5 ... and stress response pathways involving the repair of tRNA breaks (during tRNA splicing) and mRNA breaks (during the unfolded protein ...

Despite these structural features, mRNA molecules are relatively unstable compared to DNA. They have a shorter lifespan and are prone to degradation by cellular enzymes called ribonucleases (RNases).