Lipid nanoparticles have been studied ... low tissue penetration and minimal transfection efficiency (how effectively mRNA material is delivered and expressed in target cells).

Ionizable lipid nanoparticles (LNPs ... approach to identify an LNP formulation that delivers therapeutic mRNA to the placenta and alleviates hypertension in mouse models of pre-eclampsia.

Lipid nanoparticles containing acid degradable lipids transfected multiple non-liver organs after an intravenous injection and efficiently transfected brain tissue after an intracranial injection. The ...

such as direct injection of naked mRNA, lipid-based carriers, polymers, and protein derivatives. Those COVID vaccines that have experienced success are based around lipid nanoparticle delivery.

This lipid core provides a hydrophobic environment ideal for encapsulating genetic materials such as messenger RNA (mRNA) or small interfering RNA (siRNA). LNPs typically contain ionizable lipids, ...

today announced that its nanoparticle-based delivery platform was successfully tested also for circular mRNA. In vitro experiments demonstrated successful transfection of cells and significantly ...

We used lipid nanoparticles to deliver mRNA and siRNA to human PCa cells to evaluate our technique's ability to both restore the lost PTEN and silence the overexpressed AR. Our strategy could also ...

The recent success of the mRNA-LNP vaccines fueled biopharma to explore lipid-based nanoparticles for advanced drug delivery. The industry is now poised to exploit the full therapeutic potential ...

and lipid nanoparticles for mRNA delivery. The POx-based lipid nanoparticles were comparable in transfection capability to their PEGylated counterparts. Also, the prophylactic effect in SARS-CoV-2 ...

Function-engineerable nanoparticles in combination with the advantageous effects of various functional lipid components enable achievement of enhanced blood stability, decreased toxicity and ...

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