Professor Hirohide Saito (Department of Life Science Frontiers at CiRA / The University of Tokyo) and Assistant Professor ...

This unique property facilitates membrane fusion-mediated endosomal escape, leading to improved mRNA expression in the liver compared to conventional phospholipids such as DSPC and DOPE. "Endosomal ...

Investigating how mutations in tumors alter DNA’s 3D structure—and subsequently, regulatory sequences called enhancers—can ...

Additionally, mRNA expression lasted up to four weeks -- significantly longer than the typical five-day expression period of LNPs. Notably, ...

The mRNA is expressed in target cells for clinical translation and purified by high-performance liquid chromatography to remove double-stranded RNA contaminants and increase protein expression in ...

In addition, ME Therapeutics is exploring design modifications of its mRNA candidates to modulate mRNA expression in a tissue-specific manner for increased efficacy and safety. About ME Therapeutics.

Researchers examined the vaccination effects and local antigen expression efficiency of a needle-free vaccination technique involving pyro-drive liquid jet injection (PYRO) to deliver the naked ...

For the first time, systemically delivered programmable mRNA was used to safely target expression of IL-12 into cancerous tissue while inhibiting expression in healthy tissue,” said Jacob ...

As the first vaccines for Covid-19 rolled out at the end of 2020, messenger RNA catapulted into public awareness. Now, a few years later, interest in mRNA has exploded.Clinical trials are underway ...

Conclusions: This mRNA-based biomarker analysis demonstrated that SG improves PFS and OS outcomes in patients with pretreated, endocrine-resistant HR+/HER2– mBC regardless of Trop-2 mRNA expression.

Researchers are testing the use of mRNA to get damaged livers to repair themselves, in a move that could one day lessen the need for organ transplants.

India's first home-grown Covid-19 mRNA vaccine uses self-amplifying RNA technology, can be stored in a conventional refrigerator instead of special freezers, and doesn't require a needle. It marks ...