The new CBC-ALYREF structure revealed molecular insights into the ALYREF-mediated recruitment of mRNA export machinery to the 5' end of nascent mRNA transcripts. The structure, along with ...

The popularity of mRNA-based therapeutics has surged over the past few years. To ensure the safety of these treatments, scientists need to analyze the characteristics of the manufactured molecules, ...

The central dogma of molecular biology suggests that the primary role of RNA is to convert the information stored in DNA into proteins. In reality, there is much more to the RNA story.

They tested mRNA structures with zero to three branches and three different kinds of chemical modifications. The modifications were phosphorothioate (PS), DNA, and 2’-O-methoxyethyl (2MOE).

Details appeared recently in Nature Biomedical Engineering, in an article titled, “Optimization of the activity and biodegradability of ionizable lipids for mRNA delivery via directed chemical ...

By adjusting the chemical structure of lipid nanoparticles, the researchers were able to target different organs, presaging a new era in precision medicine. Credit: Lulu Xue and Michael J. Mitchell ...

Mammalian Oocytes Store mRNA in Newly Found Membraneless Structure. The findings answer the longstanding question of where these cells hold the mRNA needed to cope with the transcriptional halt ...

A study in the Journal of the American Chemical Society reports steps toward making inhalable mRNA medicines a possibility. Researchers outline their improved lipid-polymer nanoparticle for holding ...

In a new paper published in Nature Nanotechnology ("Combinatorial design of siloxane-incorporated lipid nanoparticles augments intracellular processing for tissue-specific mRNA therapeutic delivery"), ...