UNO reverse card memes have become the fastest way to shut down an argument, flip the script on someone (or something) coming at you, and overall just win against any theoretical opponent.

The current deck comes with four blank wild cards ... is a whole corner of Instagram and Twitter that moves via memes and Uno is probably the most meme-able card game on earth.

Twitter users are using the card game Uno to meme their most relatable moments. Using Uno’s infamous “draw four” card, people are challenging their followers to do something they hate—or ...

In some games, phoning an old friend in the middle of a round can be a helpful strategy (or an actual “lifeline”), but an ex? Not so preferable. That cold hard truth is now on full display ...