Ribosomes are the sites in a cell in which protein synthesis takes place. Cells have many ribosomes, and the exact number depends on how active a particular cell is in synthesizing proteins.

At this point, translation must be terminated, and the nascent protein must be released from the mRNA and ribosome. Termination of Translation There are three termination codons that are employed ...

During translation, multiple ribosomes travel along the nucleic acid chain to build polypeptides that become functional proteins. Occasionally, these molecular decoders pause on the mRNA, either ...

The process of translation by ribosomes, which functions as a factory of protein synthesis, may be impeded by ‘ribosome arrest peptides’ (RAPs). However, underlying mechanisms remain elusive.

Proteins form the structural and functional backbone of the cell, and any perturbation in their synthesis can disrupt normal cellular functions. The ...

Proteins form the structural and functional backbone of the cell, and any perturbation in their synthesis can disrupt normal ...

HHMI scientists and their colleagues discover a new mechanism of protein synthesis. Ribosomes are the cell’s molecular machines, responsible for translating genetic information in messenger RNA into ...

We showed that non-AUG translation is strikingly resistant to multiple protein synthesis inhibitors, including cycloheximide. We find that these inhibitors slow elongating ribosomes, thereby inducing ...

Researchers from the Tanenbaum group at the Hubrecht Institute have developed a novel microscopy technique to observe ...

The catalytic center of the ribosome, known as the peptidyl transferase center (PTC), is composed entirely of rRNA. The PTC is highly conserved across all domains of life, highlighting the fundamental ...

We call this a complementary copy. The newly formed strand of mRNA is now ready to leave the nucleus and travel to the ribosome. After translation, the polypeptide is finally folded into the ...