Ribosomes are the sites in a cell in which protein synthesis takes place. Cells have many ribosomes, and the exact number depends on how active a particular cell is in synthesizing proteins.

At this point, translation must be terminated, and the nascent protein must be released from the mRNA and ribosome. Termination of Translation There are three termination codons that are employed ...

During translation, multiple ribosomes travel along the nucleic acid chain to build polypeptides that become functional proteins. Occasionally, these molecular decoders pause on the mRNA, either ...

HHMI scientists and their colleagues discover a new mechanism of protein synthesis. Ribosomes are the cell’s molecular machines, responsible for translating genetic information in messenger RNA into ...

Kathrin Leppek at the Institute of Clinical Chemistry and Clinical Pharmacology (IKCKP) at the UKB is investigating the control of translation using the direct interaction of the ribosome with mRNAs.

Kathrin Leppek at the Institute of Clinical Chemistry and Clinical Pharmacology (IKCKP) at the UKB is investigating the control of translation using the direct interaction of the ribosome with mRNAs.

We showed that non-AUG translation is strikingly resistant to multiple protein synthesis inhibitors, including cycloheximide. We find that these inhibitors slow elongating ribosomes, thereby inducing ...

Within a cell, DNA carries the genetic code for building proteins. To build proteins, the cell makes a copy of DNA, called mRNA. Then, another molecule called a ribosome reads the mRNA, translating it ...

Kathrin Leppek at the Institute of Clinical Chemistry and Clinical Pharmacology (IKCKP) at the UKB is investigating the control of translation using the direct interaction of the ribosome with mRNAs.

The catalytic center of the ribosome, known as the peptidyl transferase center (PTC), is composed entirely of rRNA. The PTC is highly conserved across all domains of life, highlighting the fundamental ...

We call this a complementary copy. The newly formed strand of mRNA is now ready to leave the nucleus and travel to the ribosome. After translation, the polypeptide is finally folded into the ...

rRNA molecules, along with ribosomal proteins, form the structure of the ribosomes and catalyze the formation of peptide bonds between amino acids during translation. RNA synthesis, or transcription, ...