Heidelberg biochemists and structural biologists from Shanghai unravel the roles of two key regulatory factors in mRNA ...

mRNA splicing is a fundamental part of the process that occurs when encoded DNA instructions are turned into a functional ...

1 Alternative splice sites tend to be suboptimal allowing for modulation by RBPs. At the posttranscriptional level, nonsense mediated decay (NMD) is a process closely linked to alternative splicing ...

RNA splicing is a cellular process that is critical for gene expression. After genes are copied from DNA into messenger RNA, ...

The snRNAs in the snRNP complex make the splicing process more specific by recognizing the sequences of critical splicing signals at the 5' and 3' ends, as well as at the branch site of introns.

This process is known as splicing. Ultimately, the spliced messenger RNA consists of only protein-encoding exons. Splicing is catalyzed by a large molecular machine. This spliceosome is made up of ...

Cambridge, Massachusetts-based Envisagenics focuses on using AI to analyse errors in RNA splicing, a process in which a precursor form of messenger RNA (mRNA) – which is used as a template for ...

These pre-mRNA molecules go through a modification process in the nucleus called splicing during which the noncoding introns are cut out and only the coding exons remain. Splicing produces a ...