A riboswitch can adopt different secondary structures to effect gene regulation depending on whether ligand is bound. This schematic is an example of a riboswitch that controls transcription. When ...

Earlier research from the Walter lab revealed that transcriptional pausing is switched on and off as a function of the preQ 1 molecule binding to the riboswitch. Moving forward, the Walter lab ...

The SAM-I, SAM-II, and SAM-III riboswitch classes are members of the SAM riboswitch family. The aptamer domain from each class has unique secondary (top row) and tertiary (bottom row) structural ...

The riboswitch was designed to regulate the expression of human erythropoietin (hEPO). This protein is used to treat anemia associated with chronic kidney disease and is an attractive target for ...

However, all such sensors reported to date are based on prokaryotic cell-free systems and therefore do not function well at room temperature. There are also problems with riboswitch design that ...

The new study shows that a particular riboswitch does not respond to just a single metabolite, as had been assumed, but rather to many such compounds. Switching Genes On and Off.

As to the riboswitch, this is an oral, small molecule inducer. When it is absent, the therapy does not produce the specific protein expression it is intended to do.

A riboswitch is a segment of messenger RNA (mRNA) that typically interacts with an effector molecule to regulate translation of the mRNA. Riboswitches contain two functional parts, the aptamer, which ...

Snap-lock mechanism in bacterial riboswitch Chemists could point way to new antibiotics Date: May 21, 2018 Source: Rice University Summary: In a discovery that points to potential new antibiotic ...

RNA self-regulation is as complex and sophisticated as protein-based gene regulation, according to a report in Science this week. A novel Bacillus subtilis riboswitch as described by the authors is an ...

In experiments at SLAC's Linac Coherent Light Source, riboswitch crystals and adenine molecules were pumped into a mixing chamber, where they were allowed to interact for carefully timed intervals ...

Part of a riboswitch WIKIMEDIA, FDARDEL Researchers at the pharmaceutical company Merck have identified a new bacteria-killing compound with an unusual target—an RNA regulatory structure called a ...